Bringing bright smiles

and a healthier future

to patients and their families

through innovative

nucleic acid medicine

Bringing bright smiles

and a healthier future

to patients

and their families

through innovative

nucleic acid medicine

NEWS

  • 2025.10.27 Our Study on Staple Oligomers Published in Nature Biomedical Engineering
  • 2025.10.22 Presentation at 21st Annual Meeting of the Oligonucleotide Therapeutics Society (OTS2025) 
  • 2025.06.23 The researchers’ efforts were featured on TV Asahi’s “Telementary”
  • 2025.04.09 Presentation at CPHI Japan 2025
  • 2025.01.10 The researcher’s efforts were featured in a special program on KAB Kumamoto Asahi Broadcasting

ABOUT

StapleBio is a seed-stage biotech company founded in 2021. Our core platform is based on Staple oligomers, which selectively hybridize with target mRNAs and induce the formation of RNA G-quadruplex (rG4) structures to precisely modulate protein expression—either downregulation or upregulation, depending on the therapeutic objectives. Our mission is to develop safe and precise novel therapeutics for rare, intractable diseases and emerging infectious diseases by leveraging this unique mechanism which enables exceptional target specificity and significantly minimizes off-target effects.

SCIENCE

What Staple Oligomers Can Do

Distinguishing Features of Staple Oligomers

  • Downregulate disease-causing proteins
  • Upregulate the proteins essential for life
  • Inhibit viral replication
  • Skip (delete) abnormal protein sequences

Distinguishing Features of
Staple Oligomers

Distinguishing Features of Staple Oligomers

  • High target gene selectivity with minimal off-target effects
  • Excellent in vivo stability
  • Broad therapeutic applicability to various diseases

CONTACT

For inquiries regarding our technology or collaborative research and development, please feel free to contact us.