
Bringing bright smiles
and a healthier future
to patients and their families
through innovative
nucleic acid medicine
Bringing bright smiles
and a healthier future
to patients
and their families
through innovative
nucleic acid medicine
NEWS

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The researcher’s efforts were featured in a special program on KAB Kumamoto Asahi Broadcasting -
Presentation at 20th Annual Meeting of the Oligonucleotide Therapeutics Society (OTS2024) -
StapleBio Inc. Triumphed as Japan Kyushu Reginal Winner at Startup World Cup 2024 -
Presentation at 9th Annual Meeting of the Japanese Society for Nucleic Acid Medicine -
Radio Interview on J-WAVE “INNOVATION WORLD TDK DREAM PITCH” program
ABOUT

StapleBio is a seed-stage biotech company founded in 2021. Our core platform is based on Staple oligomers, which selectively hybridize with target mRNAs and induce the formation of RNA G-quadruplex (rG4) structures to precisely modulate protein expression—either downregulation or upregulation, depending on the therapeutic objectives. Our mission is to develop safe and precise novel therapeutics for rare, intractable diseases and emerging infectious diseases by leveraging this unique mechanism which enables exceptional target specificity and significantly minimizes off-target effects.
SCIENCE


What Staple Oligomers Can Do
- Downregulate disease-causing proteins
- Upregulate the proteins essential for life
- Inhibit viral replication
- Skip (delete) abnormal protein sequences
Distinguishing Features of
Staple Oligomers
- High target gene selectivity with minimal off-target effects
- Excellent in vivo stability
- Broad therapeutic applicability to various diseases


