
Bringing bright smiles
and a healthier future
to patients and their families
through innovative
nucleic acid medicine
Bringing bright smiles
and a healthier future
to patients
and their families
through innovative
nucleic acid medicine
NEWS

-
Our Study on Staple Oligomers Published in Nature Biomedical Engineering -
Presentation at 21st Annual Meeting of the Oligonucleotide Therapeutics Society (OTS2025) -
The researchers’ efforts were featured on TV Asahi’s “Telementary” -
Presentation at CPHI Japan 2025 -
The researcher’s efforts were featured in a special program on KAB Kumamoto Asahi Broadcasting
ABOUT

StapleBio is a seed-stage biotech company founded in 2021. Our core platform is based on Staple oligomers, which selectively hybridize with target mRNAs and induce the formation of RNA G-quadruplex (rG4) structures to precisely modulate protein expression—either downregulation or upregulation, depending on the therapeutic objectives. Our mission is to develop safe and precise novel therapeutics for rare, intractable diseases and emerging infectious diseases by leveraging this unique mechanism which enables exceptional target specificity and significantly minimizes off-target effects.
SCIENCE


What Staple Oligomers Can Do
- Downregulate disease-causing proteins
- Upregulate the proteins essential for life
- Inhibit viral replication
- Skip (delete) abnormal protein sequences
Distinguishing Features of
Staple Oligomers
- High target gene selectivity with minimal off-target effects
- Excellent in vivo stability
- Broad therapeutic applicability to various diseases


